Objective: To evaluate the effects of WeChat-based continuity of care on psychological status, treatment outcomes, and complications in patients with eyelid tumors treated with ultrapulse CO₂ laser. Methods: A retrospective historical control study was conducted, including 100 patients with eyelid tumors who underwent ultrapulse CO₂ laser treatment at Zhongshan Ophthalmic Center, Sun Yat-sen University from June 2018 to June 2023. Patients were divided into continuity of care group (n=50) and non-continuity of care group (n=50) based on whether they received continuity of care. The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to assess patients' psychological status before and after nursing intervention. Psychological status, nursing satisfaction, and complications were compared between the two groups. Results: The continuity of care group included 12 males (24.0%) and 38 females (76.0%) with a mean age of (37.9±20.0) years; the non-continuity of care group included 19 males (38.0%) and 31 females (62.0%) with a mean age of (36.9±20.4) years. No significant differences were found in baseline characteristics including age, gender, and tumor features between the two groups (P>0.05). For psychological status scores, the continuity of care group showed mean decreases in SAS and SDS scores of (23.38±4.94) points and (21.98±5.38) points respectively, while the non-continuity of care group showed mean increases of (15.58±5.16) points and (3.78±5.45) points respectively. The between-group differences were 38.96 points (95%CI: 36.78-41.14) for SAS scores and 25.76 points (95%CI: 23.94, 27.58) for SDS scores, both statistically significant (P<0.001; P=0.025). The non-continuity of care group had significantly higher rates of concerns about wound healing process, scar formation, and appearance impact compared to the continuity of care group (all P<0.001). The total satisfaction rate was 100.0% in the continuity of care group, significantly higher than 88.0% in the non-continuity of care group (P=0.006). Both groups achieved 100% treatment effectiveness, with cure rates of 92% and 90% respectively, showing no statistical difference (P=0.749). The total complication rate in the continuity of care group was 34.0%, significantly lower than 48.0% in the non-continuity of care group (P=0.043). Conclusions: WeChat platform-based continuity of care can significantly improve anxiety and depression in patients with eyelid tumors treated with ultrapulse CO₂ laser, reduce complication rates, enhance patient satisfaction, and promote harmonious doctor-patient relationships, demonstrating important clinical application value.